FMRI activity during associative encoding is correlated with cardiorespiratory fitness and source memory performance in older adults.

ABSTRACT: Older adults (OA), relative to young adults (YA), exhibit age-related alterations in functional Magnetic Resonance Imaging (fMRI) activity during associative encoding, which contributes to deficits in source memory. Yet, there are remarkable individual differences in brain health and memory performance among OA. Cardiorespiratory fitness (CRF) is one individual difference factor that may attenuate brain aging, and thereby contribute to enhanced source memory in OA. To examine this possibility, 26 OA and 31 YA completed a treadmill-based exercise test to evaluate CRF (peak VO₂) and fMRI to examine brain activation during a face-name associative encoding task. Our results indicated that in OA, peak VO₂ was positively associated with fMRI activity during associative enco

SUBMITTER: Hayes SM 

PROVIDER: S-EPMC5674520 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature