Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers.

ABSTRACT:

Background & objectives

Rheumatic fever (RF) and rheumatic heart disease (RHD) are the autoimmune sequelae caused by Group A Streptococcus. RHD still remains a major concern in the developing countries due to its poor diagnosis, lack of vaccines and social awareness among population. This study was aimed to identify the plausible early- and late-stage disease markers associated with RF/RHD.

Methods

A total of 84 patients with confirmed pharyngitis (n=18), RF (n=23) and RHD (n=43) were included in the comparative analysis of different factors involved in host-pathogen interaction during RF/RHD pathogenesis.

Results

This study revealed high titre of serum antistreptolysin O (ASO) antibody in pharyngitis compared to RF and RHD patients, whereas procollagen type 1 C-pepti

SUBMITTER: Sarkar S 

PROVIDER: S-EPMC5674546 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature