Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice.

ABSTRACT: Advanced age is associated with chronic low-grade inflammation, which is usually referred to as inflammaging. Elderly are also known to have an altered gut microbiota composition. However, whether inflammaging is a cause or consequence of an altered gut microbiota composition is not clear. In this study, gut microbiota from young or old conventional mice was transferred to young germ-free (GF) mice. Four weeks after gut microbiota transfer immune cell populations in spleen, Peyer's patches, and mesenteric lymph nodes from conventionalized GF mice were analyzed by flow cytometry. In addition, whole-genome gene expression in the ileum was analyzed by microarray. Gut microbiota composition of donor and recipient mice was analyzed with 16S rDNA sequencing. Here, we show by transferring aged mi

SUBMITTER: Fransen F 

PROVIDER: S-EPMC5674680 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature