Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases.

ABSTRACT:

Background

Mortality rates of pancreatic cancer remain high, which is mainly due to advanced disease and metastasis. We hypothesized that genomic copy number alterations are enriched in metastatic cells compared to autologous primary tumors, which may inform on cancer-related pathways possibly serving as potential targets for specific therapies. We investigated 18 pancreatic ductal adenocarcinomas, including 39 lymph node and 5 distant metastases after surgical resection. Analysis was performed with array-based comparative genomic hybridization (aCGH).

Results

Metastases acquire a higher frequency of copy number alterations with the highest in distant metastasis (median = 42, lymph node metastases: median = 23, primary tumors: median = 17). In lymph node metastases, gains we

SUBMITTER: Rausch V 

PROVIDER: S-EPMC5674747 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature