Synthesis of [¹⁸ F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones.

ABSTRACT: A practical method for radiofluorination of anilines with [¹⁸ F]fluoride via N-arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective ¹⁸ F-labeling to prepare [¹⁸ F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an ¹⁸ F-labeled neuropeptide.

SUBMITTER: Narayanam MK 

PROVIDER: S-EPMC5674999 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature