Associations of cord blood metabolites with perinatal characteristics, newborn anthropometry, and cord blood hormones in project viva.

ABSTRACT:

Context

Metabolomics has emerged as a powerful tool to characterize biomarkers and elucidate physiological processes underlying adverse health outcomes. Little is known of these relationships during gestation and infancy, which are critical period for development of metabolic disease risk.

Objectives

To identify cord blood metabolite patterns associated with birth size; and to investigate relations of the birth size-associated metabolite patterns, and a branched chain amino acid (BCAA) metabolite pattern with a range of newborn and perinatal characteristics.

Methods

Using untargeted mass-spectrometry, we quantified metabolites in cord blood of 126 mother-child pairs. After excluding 103 xenobiotics, we used principal components analysis (PCA) to consolidate the remain

SUBMITTER: Perng W 

PROVIDER: S-EPMC5675164 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature