Adipose Stem Cell Therapy Mitigates Chronic Pancreatitis via Differentiation into Acinar-like Cells in Mice.

ABSTRACT: The objective of this study was to assess the capacity of adipose-derived mesenchymal stem cells (ASCs) to mitigate disease progression in an experimental chronic pancreatitis mouse model. Chronic pancreatitis (CP) was induced in C57BL/6 mice by repeated ethanol and cerulein injection, and mice were then infused with 4 × 10⁵ or 1 × 10⁶ GFP⁺ ASCs. Pancreas morphology, fibrosis, inflammation, and presence of GFP⁺ ASCs in pancreases were assessed 2 weeks after treatment. We found that ASC infusion attenuated pancreatic damage, preserved pancreas morphology, and reduced pancreatic fibrosis and cell death. GFP⁺ ASCs migrated to pancreas and differentiated into amylase⁺ cells. In further confirmation of the plasticity of ASCs, ASC

SUBMITTER: Sun Z 

PROVIDER: S-EPMC5675167 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature