Recurrence quantification analysis to characterize cyclical components of environmental elemental exposures during fetal and postnatal development.

ABSTRACT: Environmental exposures to essential and toxic elements may alter health trajectories, depending on the timing, intensity, and mixture of exposures. In epidemiologic studies, these factors are typically analyzed as a function of elemental concentrations in biological matrices measured at one or more points in time. Such an approach, however, fails to account for the temporal cyclicity in the metabolism of environmental chemicals, which if perturbed may lead to adverse health outcomes. Here, we conceptualize and apply a non-linear method-recurrence quantification analysis (RQA)-to quantify cyclical components of prenatal and early postnatal exposure profiles for elements essential to normal development, including Zn, Mn, Mg, and Ca, and elements associated with deleterious health effects or

SUBMITTER: Curtin P 

PROVIDER: S-EPMC5675384 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature