Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model.

ABSTRACT:

Background

Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury.

Objectives

To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation.

Methods

5-12 week-old female B

SUBMITTER: Cagle LA 

PROVIDER: S-EPMC5675408 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature