Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood.

ABSTRACT:

Objective

Previous studies have found preliminary evidence for associations between common single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor gene CNR1 and cannabis use and dependence. The present study examined a set of eight independent SNPs in or near CNR1 in relation to cannabis use measured longitudinally across emerging adulthood.

Method

Using latent growth curve modeling of 10 waves of longitudinal data spanning mean ages 18.4-23.8 years in a sample of non-Hispanic White individuals (n = 334), we tested if genotype at each CNR1 SNP was associated with both level and growth of cannabis use over time. Peer group drug use, a known correlate of individual use, was evaluated as a time-varying predictor of cannabis use and as a moderator of the relationship

SUBMITTER: Ashenhurst JR 

PROVIDER: S-EPMC5675419 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature