Recombinant LCMV Vectors Induce Protective Immunity following Homologous and Heterologous Vaccinations.

ABSTRACT: Successful vaccination against cancer and infectious diseases relies on the induction of adaptive immune responses that induce high-titer antibodies or potent cytoxic T cell responses. In contrast to humoral vaccines, the amplification of cellular immune responses is often hampered by anti-vector immunity that either pre-exists or develops after repeated homologous vaccination. Replication-defective lymphocytic choriomeningitis virus (LCMV) vectors represent a novel generation of vaccination vectors that induce potent immune responses while escaping recognition by neutralizing antibodies. Here, we characterize the CD8 T cell immune response induced by replication-defective recombinant LCMV (rLCMV) vectors with regard to expansion kinetics, trafficking, phenotype, and function and we perfor

SUBMITTER: Wingerath J 

PROVIDER: S-EPMC5675480 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature