Increased incidence of cancer and cancer-related mortality among persons with chronic hepatitis C infection, 2006-2010.

ABSTRACT:

Background & aims

Persons chronically infected with the hepatitis C virus (HCV) may be at higher risk for developing and dying from non-liver cancers than the general population.

Methods

12,126 chronic HCV-infected persons in the Chronic Hepatitis Cohort Study (CHeCS) contributed 39,984 person-years of follow-up from 2006 to 2010 and were compared to 133,795,010 records from 13 Surveillance, Epidemiology and End Results Program (SEER) cancer registries, and approximately 12 million U.S. death certificates from Multiple Cause of Death (MCOD) data. Measurements included standardized rate ratios (SRR) and relative risk (RR).

Results

The incidence of the following cancers was significantly higher among patients with chronic HCV infection: liver (SRR, 48.6 [95% CI, 44.4-52

SUBMITTER: Allison RD 

PROVIDER: S-EPMC5675515 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature