The Electrophysiological Substrate of Early Repolarization Syndrome: Noninvasive Mapping in Patients.

ABSTRACT:

Background

The early repolarization (ER) pattern is a common ECG finding. Recent studies established a definitive clinical association between ER and fatal ventricular arrhythmias. However, the arrhythmogenic substrate of ER in the intact human heart has not been characterized.

Objectives

To map the epicardial electrophysiological (EP) substrate in ER syndrome patients using noninvasive Electrocardiographic Imaging (ECGI), and to characterize substrate properties that support arrhythmogenicity.

Methods

Twenty-nine ER syndrome patients were enrolled, 17 of which had a malignant syndrome. Characteristics of the abnormal EP substrate were analyzed using data recorded during sinus rhythm. The EP mapping data were analyzed for electrogram morphology, conduction and repolar

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5675574 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature