Functional network analysis of gene-phenotype connectivity associated with temozolomide.

ABSTRACT:

Rationale

Glioma has a poor survival rate in patients even with aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for treating glioma, but TMZ treatment consistently leads to high resistance.

Aim

To investigate the underlying mechanisms of TMZ action with new therapeutic regimens in glioma.

Methods and results

The biological effects of TMZ mainly depend on the three following DNA repair systems: methylguanine methyltransferase (MGMT), mismatch repair (MMR) and base excision repair (BER). Based on related genes in these three systems, web-based tools containing data compiled from open-source databases, including DrugBank, STRING, WebGestalt and ClueGO, were queried, and five common genes along with the top fifteen pathways, including the

SUBMITTER: Shi J 

PROVIDER: S-EPMC5675653 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature