L1 cell adhesion molecule (L1CAM) is a strong predictor for locoregional recurrences in cervical cancer.

ABSTRACT:

Background

L1 cell adhesion molecule (L1CAM) has been shown to be a prognostic marker in various cancer types, and has been suggested to play a role in epithelial mesenchymal transition (EMT). Here, we determined the prognostic significance of L1CAM in cervical cancer and its association with vimentin expression on tumor cells, indicative of EMT.

Methods

Formalin-fixed, paraffin-embedded primary tumor samples from 372 cervical cancer patients were collected for immunohistochemical analysis of L1CAM expression. In 109 FFPE specimens, the percentage of vimentin expressing tumor cells was determined by flow cytometry.

Results

Positive L1CAM expression (≥10% of tumor cells) was associated with disease-free survival, validated using RNAseq TCGA data. L1CAM expression was i

SUBMITTER: Schrevel M 

PROVIDER: S-EPMC5675654 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature