Protective effect of dehydroandrographolide on obstructive cholestasis in bile duct-ligated mice.

ABSTRACT:

Background

Dehydroandrographolide (DA) is the main contributor to the therapeutic properties of the medicinal plant Andrographis paniculata (AP). However, it is unknown whether DA has a hepatoprotective effect on obstructive cholestasis in mice and humans.

Methods

We administered DA to mice for 5 days prior to bile duct ligation (BDL) and for the 7 days. Liver function markers, liver histology and necrosis, compensatory responses of hepatocytes, liver fibrosis and the expression of hepatic fibrogenesis markers were evaluated in BDL mice and/or human LX-2 cells.

Results

Mice treated with DA demonstrated lower levels of serum alanine transarninase (ALT), milder liver damage, liver necrosis and fibrosis formation than in vehicle control with carboxymethylcellulose (CMC)

SUBMITTER: Weng Z 

PROVIDER: S-EPMC5675681 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature