IGF1 gene polymorphisms associated with diabetic retinopathy risk in Chinese Han population.

ABSTRACT:

Objective

This study aimed to explore the association of insulin-like growth factor 1 gene (IGF1) polymorphisms with diabetic retinopathy (DR) in a Chinese Han population.

Methods

Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for genotyping. Genotype frequencies were compared by chi-square test. Odds ratio (OR) with 95% confidence interval (95%CI) was calculated to express the risk intensity of DR. Linkage disequilibrium between IGF1 polymorphisms was analyzed by Haploview. Serum IGF1 concentration was measured by enzyme-linked immunosorbent assays (ELISA) and assessed by student's t test.

Results

AG genotype of rs6218 and TT genotype of rs35767 were significantly associated with the elevated risk of DR (rs6218: O

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5675691 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature