CD4 effector T cell differentiation is controlled by IL-15 that is expressed and presented in trans.

ABSTRACT: T cells are both producers and consumers of cytokines, and autocrine cytokine signaling plays a critical role in T cell immunity. IL-15 is a homeostatic cytokine for T cells that also controls inflammatory immune responses. An autocrine role of T cell-derived IL-15, however, remains unclear. Here we examined IL-15 expression and signaling upon effector T cell differentiation in mice, and, surprisingly, found that CD4 T cells did not express IL-15. CD4 T cells lacked Il15 gene reporter activity, did not contain IL-15 transcripts, and did not produce IL-15Rα, the proprietary IL-15 receptor required for IL-15 trans-presentation. Moreover, IL-15 failed to inhibit Th17 cell differentiation and failed to generate Foxp3⁺ Treg cells in vitro. IL-2, which utilizes the same IL-2Rβ/γc rece

SUBMITTER: Waickman AT 

PROVIDER: S-EPMC5675755 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature