A high salt diet inhibits obesity and delays puberty in the female rat.

ABSTRACT:

Background/objectives

Processed foods are considered major contributors to the worldwide obesity epidemic. In addition to high sugar and fat contents, processed foods contain large amounts of salt. Owing to the correlations with rising adiposity, salt has recently been proposed to be obesogenic. This study investigated three hypotheses: (i) high salt contributes to weight gain and adiposity in juvenile female rats, (ii) puberty onset would be altered because salt is known to affect neuronal systems involved in activating the reproductive system, and (iii) enhanced adiposity will act synergistically with salt to drive early puberty onset.

Design

Female weanling rats (post-natal day 21, n=105) were fed a low fat/low salt diet, low fat/high salt diet, high fat/low salt diet or

SUBMITTER: Pitynski-Miller D 

PROVIDER: S-EPMC5675756 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature