Associations between genetic and epigenetic variations in cytokine genes and mild persistent breast pain in women following breast cancer surgery.

ABSTRACT: Persistent pain following breast cancer surgery is a significant problem. Both inherited and acquired mechanisms of inflammation appear to play a role in the development and maintenance of persistent pain. In this longitudinal study, growth mixture modeling was used to identify persistent breast pain phenotypes based on pain assessments obtained prior to and monthly for 6months following breast cancer surgery. Associations between the "no pain" and "mild pain" phenotypes and single nucleotide polymorphisms (SNPs) spanning 15 cytokine genes were evaluated. The methylation status of the CpG sites found in the promoters of genes associated with pain group membership was determined using bisulfite sequencing. In the multivariate analysis, three SNPs (i.e., interleukin 6 (IL6) rs2069840, C-X-C

SUBMITTER: Stephens KE 

PROVIDER: S-EPMC5675785 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature