Efficient experimental designs for isotropic generalized diffusion tensor MRI (IGDTI).

ABSTRACT:

Purpose

We propose a new generalized diffusion tensor imaging (GDTI) experimental design and analysis framework for efficiently measuring orientationally averaged diffusion-weighted images (DWIs), which remove bulk signal modulations attributed to diffusion anisotropy and quantify isotropic higher-order diffusion tensors (HOT). We illustrate how this framework accelerates the clinical measurement of rotation-invariant tissue microstructural parameters derived from HOT, such as the HOT-Trace and the mean t-kurtosis.

Theory and methods

For a large range of b-values, we compare orientationally averaged DWIs measured with high angular resolution diffusion imaging to those obtained with the proposed isotropic GDTI (IGDTI) experimental design. We compare rotation-invariant microst

SUBMITTER: Avram AV 

PROVIDER: S-EPMC5675833 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature