Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells.

ABSTRACT: Regulatory T cells (Tregs) are potent suppressors of immune responses and are currently being clinically tested for their potential to stop or control undesired immune responses in autoimmunity, hematopoietic stem cell transplantation, and solid organ transplantation. Current clinical approaches aim to boost Tregs in vivo either by using Treg-promoting small molecules/proteins and/or by adoptive transfer of expanded Tregs. However, the applicability of Treg-based immunotherapies continues to be hindered by technical limitations related to cell isolation and expansion of a pure, well-characterized, and targeted Treg product. Efforts to overcome these limitations and improve Treg-directed therapies are now under intense investigation in animal models and pre-clinical studies. Here, we

SUBMITTER: Dawson NAJ 

PROVIDER: S-EPMC5675854 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature