Subtle Microbiome Manipulation Using Probiotics Reduces Antibiotic-Associated Mortality in Fish.

ABSTRACT: Prophylactic antibiotics in the aquaculture and ornamental fish industry are intended to prevent the negative impacts of disease outbreaks. Research in mice and humans suggests that antibiotics may disturb microbiome communities and decrease microbiome-mediated disease resistance, also known as "colonization resistance." If antibiotics impact fish as they do mice and humans, prophylactic administrations on aquaculture farms may increase downstream disease susceptibility in target hosts, despite short-term pathogen control benefits. We tested the effects of antibiotics on mortality after a pathogen challenge in the Poecilia sphenops black molly and subsequently tested if probiotic inoculations could reverse any antibiotic-induced losses of disease resistance. We found that antibiotic

SUBMITTER: Schmidt V 

PROVIDER: S-EPMC5675916 | biostudies-literature | 2017 Nov-Dec

REPOSITORIES: biostudies-literature