MiR-155 induces ROS generation through downregulation of antioxidation-related genes in mesenchymal stem cells.

ABSTRACT: Inflammation-induced reactive oxygen species (ROS) are implicated in cellular dysfunction and an important trigger for aging- or disease-related tissue degeneration. Inflammation-induced ROS in stem cells lead to deterioration of their properties, altering tissue renewal or regeneration. Pathological ROS generation can be induced by multiple steps, and dysfunction of antioxidant systems is a major cause. The identification of the central molecule mediating the above-mentioned processes would pave the way for the development of novel therapeutics for aging, aging-related diseases, or stem cell therapies. In recent years, microRNAs (miRNAs) have been shown to play important roles in many biological reactions, including inflammation and stem cell functions. In inflammatory conditions, certain

SUBMITTER: Onodera Y 

PROVIDER: S-EPMC5676067 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature