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PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters.

ABSTRACT: The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc's binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with active genes, this interaction with Leo1 contributes to Myc targeting to open promoters.

SUBMITTER: Gerlach JM 

PROVIDER: S-EPMC5676885 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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PAF1 complex component Leo1 helps recruit <i>Drosophila</i> Myc to promoters.

Gerlach Jennifer M JM   Furrer Michael M   Gallant Maria M   Birkel Dirk D   Baluapuri Apoorva A   Wolf Elmar E   Gallant Peter P  

Proceedings of the National Academy of Sciences of the United States of America 20171016 44

The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc's binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with a  ...[more]

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