Histone methyltransferase G9a is a key regulator of the starvation-induced behaviors in Drosophila melanogaster.

ABSTRACT: Organisms have developed behavioral strategies to defend themselves from starvation stress. Despite of their importance in nature, the underlying mechanisms have been poorly understood. Here, we show that Drosophila G9a (dG9a), one of the histone H3 Lys 9-specific histone methyltransferases, functions as a key regulator for the starvation-induced behaviors. RNA-sequencing analyses utilizing dG9a null mutant flies revealed that the expression of some genes relating to gustatory perception are regulated by dG9a under starvation conditions. Reverse transcription quantitative-PCR analyses showed that the expression of gustatory receptor genes for sensing sugar are up-regulated in starved dG9a null mutant. Consistent with this, proboscis extension reflex tests indicated that dG9a depletion incr

SUBMITTER: Shimaji K 

PROVIDER: S-EPMC5676964 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature