The challenge of mapping the human connectome based on diffusion tractography.

ABSTRACT: Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in trac

SUBMITTER: Maier-Hein KH 

PROVIDER: S-EPMC5677006 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature