Ontology highlight
ABSTRACT:
SUBMITTER: Vu LP
PROVIDER: S-EPMC5677536 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Vu Ly P LP Pickering Brian F BF Cheng Yuanming Y Zaccara Sara S Nguyen Diu D Minuesa Gerard G Chou Timothy T Chow Arthur A Saletore Yogesh Y MacKay Matthew M Schulman Jessica J Famulare Christopher C Patel Minal M Klimek Virginia M VM Garrett-Bakelman Francine E FE Melnick Ari A Carroll Martin M Mason Christopher E CE Jaffrey Samie R SR Kharas Michael G MG
Nature medicine 20170918 11
N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is an abundant nucleotide modification in mRNA that is required for the differentiation of mouse embryonic stem cells. However, it remains unknown whether the m<sup>6</sup>A modification controls the differentiation of normal and/or malignant myeloid hematopoietic cells. Here we show that shRNA-mediated depletion of the m<sup>6</sup>A-forming enzyme METTL3 in human hematopoietic stem/progenitor cells (HSPCs) promotes cell differentiation, coupled wi ...[more]