A single bout of exercise increases hippocampal Bdnf: influence of chronic exercise and noradrenaline.

ABSTRACT: Research in human subjects suggests that acute exercise can improve memory performance, but the qualities of the exercise necessary to promote improved memory, and the signaling pathways that mediate these effects are unknown. Brain-derived neurotrophic factor (Bdnf), noradrenergic signaling, and post-translational modifications to AMPA receptors have all been implicated in the enhancement of memory following emotional or physical arousal; however, it is not known if a single bout of exercise is sufficient to engage these pathways. Here we use a rodent model to investigate the effects of acute and chronic exercise on hippocampal transcript-specific Bdnf expression and phosphorylation of the GluR1 subunit of the AMPA-type glutamate receptor. A single bout of treadmill exercise was insuffici

SUBMITTER: Venezia AC 

PROVIDER: S-EPMC5677569 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature