3D-Printed Paper Spray Ionization Cartridge with Integrated Desolvation Feature and Ion Optics.

ABSTRACT: In this work we present the application of 3D-printing for the miniaturization and functionalization of an ion source for (portable) mass spectrometry (MS). Two versions of a 3D-printed cartridge for paper spray ionization (PSI) are demonstrated, assessed, and compared. We first focus on the use of 3D-printing to enable the integration of an embedded electrostatic lens and a manifold for internal sheath gas distribution and delivery. Cartridges with and without a sheath gas manifold and an electrostatic lens are compared with respect to analytical performance and operational flexibility. The sensitivity and limit of detection are improved in the cartridge with an electrostatic lens and sheath gas manifold compared to the cartridge without (15% and over 6.5× smaller, respectively). The use

SUBMITTER: Salentijn GI 

PROVIDER: S-EPMC5677766 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature