Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations.

ABSTRACT: A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple sclerosis, not reported previously. Using polygenic risk scores based on public summary statistics of variants outside the major histocompatibility complex region we quantified genetic overlap between common autoimmune diseases in Icelanders and identified disease clusters characterized by autoantibody presence/absence. As multiple sclerosis-polygenic risk scores captures the risk of primary biliary cirrhosis and vice versa (P = 1.6 × 10^-7, 4.3 × 10^-9) we used primary biliary cirrhosis as a proxy-phenotype for multiple sclerosis, the idea b

SUBMITTER: Olafsson S 

PROVIDER: S-EPMC5677966 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature