Gut remediation: a potential approach to reducing chromium accumulation using Lactobacillus plantarum TW1-1.

ABSTRACT: Some lactobacilli have protective effects against some heavy metals in mammals, but the underlying mechanism is not fully understood. To evaluate the remediation potency and the mechanism of Lactobacillus against chromium (Cr) in mice, Lactobacillus plantarum TW1-1 was orally administrated to Kunming mice for 7 weeks during exposure to 1 mM K₂Cr₂O₇ in drinking water. Results showed that TW1-1 helped to decrease Cr accumulation in tissues and increase Cr excretion in feces, and may also attenuate alterations in oxidative stress and histopathological changes caused by Cr exposure. Moreover, the chromate reduction ability of fecal bacteria doubled after administration of TW1-1 upon Cr induction. MiSeq sequencing of fecal bacterial 16S rRNA genes revealed that

SUBMITTER: Wu G 

PROVIDER: S-EPMC5678100 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature