Influenza virus segment 5 (+)RNA - secondary structure and new targets for antiviral strategies.

ABSTRACT: Influenza A virus is a threat for humans due to seasonal epidemics and occasional pandemics. This virus can generate new strains that are dangerous through nucleotide/amino acid changes or through segmental recombination of the viral RNA genome. It is important to gain wider knowledge about influenza virus RNA to create new strategies for drugs that will inhibit its spread. Here, we present the experimentally determined secondary structure of the influenza segment 5 (+)RNA. Two RNAs were studied: the full-length segment 5 (+)RNA and a shorter construct containing only the coding region. Chemical mapping data combined with thermodynamic energy minimization were used in secondary structure prediction. Sequence/structure analysis showed that the determined secondary structure of segment 5 (+)

SUBMITTER: Soszynska-Jozwiak M 

PROVIDER: S-EPMC5678188 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature