Vanillin Affects Amyloid Aggregation and Non-Enzymatic Glycation in Human Insulin.

ABSTRACT: Curcumin is known for its anti-inflammatory, antioxidant and anticancer activity, as well as for its ability to interfere with amyloid aggregation and non-enzymatic glycation reaction, that makes it an attractive potential drug. However, curcumin therapeutic use is limited because of its low systemic bioavailability and chemical stability as it undergoes rapid hydrolysis in physiological conditions. Recently, much attention has been paid to the biological properties of curcumin degradation products as potential bioactive molecules. Between them, vanillin, a natural vanilla extract, is a stable degradation product of curcumin that could be responsible for mediating its beneficial effects. We have analyzed the effect of vanillin, in comparison with curcumin, in the amyloid aggregation proces

SUBMITTER: Iannuzzi C 

PROVIDER: S-EPMC5678370 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature