MiR-129-2 mediates down-regulation of progesterone receptor in response to progesterone in breast cancer cells.

ABSTRACT:

Objective

Hormonal therapy is an important component of first line of treatment for breast cancer. Response to hormonal therapy is influenced by the progesterone receptor (PR)-status of breast cancer patients. However as an early effect, exposure to progesterone decreases expression of PR in breast cancer cells. An understanding of the mechanism underlying down-regulation of PR could help improve response to hormonal therapy.

Methods

We performed small RNA sequencing of breast cancer cells for identification of microRNAs targeting PR in response to progesterone treatment. Biochemical approaches were used to validate the findings in breast cancer cells.

Results

Analysis of small RNA sequencing of four breast cancer cell lines treated with progesterone revealed an up-re

SUBMITTER: Godbole M 

PROVIDER: S-EPMC5678702 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature