Transcriptomic responses to wounding: meta-analysis of gene expression microarray data.

ABSTRACT:

Background

A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and species, including rat, mouse and human.

Results

We collected available microarray transcriptomic profiles obtained from different tissue injury experiments and selected the genes showing a minimum twofold change in expression in response to wounding in prevailing number of experiments for each of five wound healing stages we distinguished: haemostas

SUBMITTER: Sass PA 

PROVIDER: S-EPMC5678747 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature