Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice.

ABSTRACT:

Background

Transplantation of neural stem cells (NSCs) has been proposed as a promising therapeutic strategy for the treatment of ischemia/reperfusion (I/R)-induced brain injury. However, existing evidence has also challenged this therapy on its limitations, such as the difficulty for stem cells to survive after transplantation due to the unfavorable microenvironment in the ischemic brain. Herein, we have investigated whether preconditioning of NSCs with adjudin, a small molecule compound, could enhance their survivability and further improve the therapeutic effect for NSC-based stroke therapy.

Method

We aimed to examine the effect of adjudin pretreatment on NSCs by measuring a panel of parameters after their transplantation into the infarct area of ipsilateral striatum 24 h

SUBMITTER: Zhang T 

PROVIDER: S-EPMC5678778 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature