MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours.

ABSTRACT:

Background

MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. Several common oncogenic microRNAs have been found for canine mammary cancer and human breast cancer. On account of this, large-scale profiling of microRNA expression in canine mammary cancer seems to be important for both dogs and humans.

Methods

Expression profiles of 317 microRNAs in 146 canine mammary tumours of different histological type, malignancy grade and clinical history (presence/absence of metastases) and in 25 control samples were evaluated. The profiling was performed using microarrays. Significance Analysis of Microarrays test was applied in the analysis of microarray data (both un

SUBMITTER: Bulkowska M 

PROVIDER: S-EPMC5678797 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature