Validation of pathological grading systems for predicting metastatic potential in pheochromocytoma and paraganglioma.

ABSTRACT:

Purpose

The Grading system for Adrenal Pheochromocytoma and Paraganglioma (GAPP) was proposed for predicting the metastatic potential of pheochromocytoma and paraganglioma to overcome the limitations of the Pheochromocytoma of the Adrenal Scaled Score (PASS). However, to date, no study validating the GAPP has been conducted, and previous studies did not include mutations in the succinate dehydrogenase type B (SDHB) gene in the score calculation. In this retrospective cohort study, we validated the prediction ability of GAPP and assessed whether it would be improved by inclusion of the loss of SDHB immunohistochemical staining.

Methods

We divided the tumors into non-metastatic and metastatic groups based on the presence of synchronous or metachronous metastases. The GAPP scor

SUBMITTER: Koh JM 

PROVIDER: S-EPMC5678867 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature