Use of Mac-2 binding protein as a biomarker for nonalcoholic fatty liver disease diagnosis.

ABSTRACT: In contrast to patients with viral hepatitis, patients with nonalcoholic fatty liver disease (NAFLD) can progress to hepatocellular carcinoma during the initial stages of liver fibrosis. Development and implementation of noninvasive methods for diagnosis and progression prediction are important for effective NAFLD surveillance. Mac-2 binding protein (Mac-2bp) is a useful nonalcoholic steatohepatitis (NASH) diagnosis biomarker and a powerful prediction biomarker for NAFLD fibrosis stage. Wisteria floribunda agglutinin (WFA)-positive Mac-2bp (WFA⁺-M2BP) is a novel serum fibrosis biomarker for chronic hepatitis C that has clinical validity. Mac-2bp and WFA⁺-M2BP are also clinical NAFLD biomarker candidates. We examined the efficacy of Mac-2bp and WFA⁺-M

SUBMITTER: Kamada Y 

PROVIDER: S-EPMC5678915 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature