Delayed differentiation of potent effector CD8⁺ T cells reducing viremia and reservoir seeding in acute HIV infection.

ABSTRACT: CD8⁺ T cells play a critical role in controlling HIV viremia and could be important in reducing HIV-infected cells in approaches to eradicate HIV. The simian immunodeficiency virus model provided the proof of concept for a CD8⁺ T cell-mediated reservoir clearance but showed conflicting evidence on the role of these cells to eliminate HIV-infected cells. In humans, HIV-specific CD8⁺ T cell responses have not been associated with a reduction of the HIV-infected cell pool in vivo. We studied HIV-specific CD8⁺ T cells in the RV254 cohort of individuals initiating ART in the earliest stages of acute HIV infection (AHI). We showed that the HIV-specific CD8⁺ T cells generated as early as AHI stages 1 and 2 before peak viremia are delayed in e

SUBMITTER: Takata H 

PROVIDER: S-EPMC5678930 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature