Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial infection.

ABSTRACT: Many human infections are polymicrobial in origin, and interactions among community inhabitants shape colonization patterns and pathogenic potential ¹ . Periodontitis, which is the sixth most prevalent infectious disease worldwide ² , ensues from the action of dysbiotic polymicrobial communities ³ . The keystone pathogen Porphyromonas gingivalis and the accessory pathogen Streptococcus gordonii interact to form communities in vitro and exhibit increased fitness in vivo ^3,4 . The mechanistic basis of this polymicrobial synergy, however, has not been fully elucidated. Here we show that streptococcal 4-aminobenzoate/para-amino benzoic acid (pABA) is required for maximal accumulation of P. gingivalis in dual-species communities. Metabolomic and prote

SUBMITTER: Kuboniwa M 

PROVIDER: S-EPMC5678995 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature