Organic CO Prodrugs: Structure-CO-Release Rate Relationship Studies.

ABSTRACT: Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, the structure-release rate studies of the first class of organic CO prodrugs that release CO in aqueous solution at neutral pH is described.

SUBMITTER: Pan Z 

PROVIDER: S-EPMC5679012 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature