Effect of Losartan on Mitral Valve Changes After Myocardial Infarction.

ABSTRACT:

Background

After myocardial infarction (MI), mitral valve (MV) tethering stimulates adaptive leaflet growth, but counterproductive leaflet thickening and fibrosis augment mitral regurgitation (MR), doubling heart failure and mortality. MV fibrosis post-MI is associated with excessive endothelial-to-mesenchymal transition (EMT), driven by transforming growth factor (TGF)-β overexpression. In vitro, losartan-mediated TGF-β inhibition reduces EMT of MV endothelial cells.

Objectives

This study tested the hypothesis that profibrotic MV changes post-MI are therapeutically accessible, specifically by losartan-mediated TGF-β inhibition.

Methods

The study assessed 17 sheep, including 6 sham-operated control animals and 11 with apical MI and papillary muscle retraction short of

SUBMITTER: Bartko PE 

PROVIDER: S-EPMC5679094 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature