Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.

ABSTRACT: T cell specificity emerges from a myriad of processes, ranging from the biological pathways that control T cell signaling to the structural and physical mechanisms that influence how TCRs bind peptides and MHC proteins. Of these processes, the binding specificity of the TCR is a key component. However, TCR specificity is enigmatic: TCRs are at once specific but also cross-reactive. Although long appreciated, this duality continues to puzzle immunologists and has implications for the development of TCR-based therapeutics. In this review, we discuss TCR specificity, emphasizing results that have emerged from structural and physical studies of TCR binding. We show how the TCR specificity/cross-reactivity duality can be rationalized from structural and biophysical principles. There is excellen

SUBMITTER: Singh NK 

PROVIDER: S-EPMC5679125 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature