Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility.

ABSTRACT:

Background

Manganese (Mn) is an essential element required for growth and development, but higher body burdens have been associated with neurobehavioral decrements in children.

Objectives

We examined whether prenatal or postnatal Mn measured in deciduous teeth was associated with scores on a test of visuospatial learning and memory.

Methods

Deciduous teeth were collected from 142 participants (ages 10-14years) residing near varied ferro‑manganese industry in Italy. Mn concentrations were measured in prenatal and postnatal tooth regions by laser ablation inductively coupled plasma mass spectrometry (ICP-MS). The Virtual Radial Arm Maze (VRAM), an animal-human analogue task, was used to assess visuospatial learning and memory. We used generalized additive, linear and ze

SUBMITTER: Bauer JA 

PROVIDER: S-EPMC5679133 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature