In utero exposure to atrazine analytes and early menarche in the Avon Longitudinal Study of Parents and Children Cohort.

ABSTRACT:

Background

Evidence from experimental studies suggests that atrazine and its analytes alter the timing of puberty in laboratory animals. Such associations have not been investigated in humans.

Objective

To determine the association between in utero exposure to atrazine analytes and earlier menarche attainment in a nested case-control study of the population-based Avon Longitudinal Study of Parents and Children.

Methods

Cases were girls who reported menarche before 11.5 years while controls were girls who reported menarche at or after 11.5 years. Seven atrazine analyte concentrations were measured in maternal gestational urine samples (sample gestation week median (IQR): 12 (8-17)) during the period 1991-1992, for 174 cases and 195 controls using high performance liqui

SUBMITTER: Namulanda G 

PROVIDER: S-EPMC5679269 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature