Heritability of Mitral Regurgitation: Observations From the Framingham Heart Study and Swedish Population.

ABSTRACT:

Background

Familial aggregation has been described for primary mitral regurgitation (MR) caused by mitral valve prolapse. We hypothesized that heritability of MR exists across different MR subtypes including nonprimary MR.

Methods and results

Study participants were FHS (Framingham Heart Study) Generation 3 (Gen 3) and Gen 2 cohort participants and all adult Swedish siblings born after 1932 identified in 1997 and followed through 2010. MR was defined as ≥ mild regurgitation on color Doppler in FHS and from International Classification of Diseases codes in Sweden. We estimated the association of sibling MR with MR in Gen 2/Gen 3/Swedish siblings. We also estimated heritability of MR in 539 FHS pedigrees (7580 individuals). Among 5132 FHS Gen 2/Gen 3 participants with s

SUBMITTER: Delling FN 

PROVIDER: S-EPMC5679298 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature