Cytomegalovirus (CMV) Epitope-Specific CD4⁺ T Cells Are Inflated in HIV⁺ CMV⁺ Subjects.

ABSTRACT: Select CMV epitopes drive life-long CD8⁺ T cell memory inflation, but the extent of CD4 memory inflation is poorly studied. CD4⁺ T cells specific for human CMV (HCMV) are elevated in HIV⁺ HCMV⁺ subjects. To determine whether HCMV epitope-specific CD4⁺ T cell memory inflation occurs during HIV infection, we used HLA-DR7 (DRB1*07:01) tetramers loaded with the glycoprotein B DYSNTHSTRYV (DYS) epitope to characterize circulating CD4⁺ T cells in coinfected HLA-DR7⁺ long-term nonprogressor HIV subjects with undetectable HCMV plasma viremia. DYS-specific CD4⁺ T cells were inflated among these HIV⁺ subjects compared with those from an HIV^- HCMV⁺ HLA-DR7⁺ cohort or wit

SUBMITTER: Abana CO 

PROVIDER: S-EPMC5679304 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature