Intrinsic DNA curvature in trypanosomes.

ABSTRACT:

Background

Trypanosoma cruzi and Trypanosoma brucei are protozoan parasites causing Chagas disease and African sleeping sickness, displaying unique features of cellular and molecular biology. Remarkably, no canonical signals for RNA polymerase II promoters, which drive protein coding genes transcription, have been identified so far. The secondary structure of DNA has long been recognized as a signal in biological processes and more recently, its involvement in transcription initiation in Leishmania was proposed. In order to study whether this feature is conserved in trypanosomatids, we undertook a genome wide search for intrinsic DNA curvature in T. cruzi and T. brucei.

Results

Using a region integrated intrinsic curvature (RIIC) scoring that we previously developed, a non-r

SUBMITTER: Smircich P 

PROVIDER: S-EPMC5679330 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature